Catalog No. : COV-500429

E220 evolution Focused-ultrasonicator

E220 evolution Focused-ultrasonicator


High performance sample preparation that grows with your needs
  • Process 1 to 8 samples in a batch
  • Upgrade to 96 samples when needed
The versatility of the E220evolution Focused-ultrasonicator makes it possible to bring the advantages of AFA to numerous biological and chemical applications including: DNA and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization. The E220evolution enables multi-sample, batch preparation, capable of processing a wide range of sample types and volumes and may be programed to process from 1 to 8 samples in a single batch. And, when workload increases, the E220evolution can be upgraded to an E220 capable of processing 1-96 samples/run or to an LE220 for high throughput processing without purchasing a new instrument.

Same applications and protocols for all 3 (E220evolutionE220, LE220) high-throughput instruments
  • DNA and RNA extraction from FFPE samples with truXTRAC™
  • DNA and RNA shearing for Next-Generation Sequencing with microTUBEs™
  • Chromatin shearing for ChIP samples with truChIP™
  • DNA extraction and purification from dried blood spots (DBS)
  • Ideal for NeoPrep with up to 8 samples sheared per batch
Covaris Adaptive Focused Acoustics provides unmatched energy control across a wide range of sample prep applications.
Isothermal processing
No heat damage, higher recovery
Non-contact, closed vessel
No cross contamination, no aerosols, no clean up
Precisely controlled and adjustable energy delivery
Standardized processes, highly reproducible
Automation ready
Integrates into customers’ sample processing work flow
Multi-sample capability
Higher productivity, less operator intervention
Broad sample volume range
One instrument for multiple applications
ItemSize Application Price
E220 evolution Focused-ultrasonicator

1 Unit

Shearing Next Gen Sequencing Automation Please Inquire

Treatment System
Bench-top: high intensity acoustic transducer, sample positioning system, temperature monitoring device, circulation pump, and water bath with safety enclosure
Treatment Power
100 Watts Average Power
24” W x 30” D x 19” H (61cm x 76cm x 48cm)
Approximately 110 lbs (50 Kg)
Meets Low Voltage Directive 2006/95/EC. Tested to EN/UL/CSA 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control and Laboratory Use, Part 1: General Requirements”
Water Conditioning
System Accessory to the E220evolution system water bath, automatically circulates water through a 0.5micron particulate filter and ultraviolet (UV) lamp system, helps to keep water clean and free of algae growth for up to one year. Uses 100-240VAC. Includes hose connections to E-series water bath.
Notebook (Computer may be supplied by Covaris or by the user)
Operating System
Windows 7 or newer
Application Software
Covaris SonoLab
Data Input
Keyboard, mouse
Chiller/heater re-circulating system – not included (may be supplied by Covaris or the user).Connect with the 3/8 inch I.D. hoses and quick connect fittings supplied
Meets EMC Directive 2004/108/EC. Tested to EMI emissions requirements for Industrial Scientific or Medical(ISM) equipment EN55011:1998 + A2:2002 Class A Group1 and EMC requirements – Electrical Equipment for Measurement, Control, and Laboratory Use EN 61326-1:2005 Table 2, EN 61000-3-2:2004 and EN 61000-3-3:1995 +A1:2001
Water Bath
Distilled or deionized water only
Water Temperature Alarm Limit
Can be set at +5.0C to +40.0C
Power Requirements
E100-120, 200-240 V~ 50-60Hz, 500 VAC
Operating Conditions
Ambient Temperature: 19°C to 25°C  (66°F to 77°C)
Relative humidity
30% to 70%
Broad Range of Applications
In life science and pharmaceutical research, the following are some of the areas E-Series are used:
  • DNA fragmentation
  • Compound formulation
  • Chromatin shearing
  • Dried Blood Spots
  • NGS-grade DNA/RNA Extraction from FFPE Tissue Samples
  • Methyl-Seq Assays
  • Cell spore and organelle Lysis
  • Tissue disruption and homogenization
  • Nanoparticle formation – micronization

Complementary Products

  • AFA compatible tubes and consumables
  • microTUBES
  • miniTUBES
  • 8 microTUBE Strip
  • Water Conditioning System

Please Inquire