Catalog No. : COV-500239

E220 Focused-ultrasonicator

E220 Focused-ultrasonicator


The E220 Focused-ultrasonicators are versatile instruments engineered for pre-analytical sample processing by Adaptive Focused Acoustics™ . Utilizing a dish-shaped acoustic transducer and computer controlled electronics; acoustic energy can be tuned to be delivered precisely and accurately to samples of varying volumes.

The E220 enables multi-sample, batch preparation, capable of processing a wide range of sample types and volumes. The E220 may be programed to process from 1 to 96 samples in a single batch. For example, with 96 samples, 96 different AFA energies may be pre-programmed. With the available racks, the E220 instrument is easily configured for use with all AFA Tubes (volumes from 50µl to 10ml) including single AFA microTUBE™ and the AFA 96 microTUBE Plate, for both single and batch sample processing. The E220 can be operated as a stand-alone unit, or easily integrated as part of an automated laboratory system.

The versatility of the E-Series Focused-ultrasonicator makes it possible to bring the advantages of AFA  to numerous biological and chemical applications including, DNA and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization.

Focused-ultrasonicators operate at frequencies well beyond the range of human hearing (500KHz) so, unlike traditional (low frequency) laboratory sonicators they are inaudible and do not require sound-proof boxes or other special precautions.
The E220 is also available in higher power (E220X) and robotic capable (E220R) configurations.

Covaris Adaptive Focused Acoustics provides unmatched energy control across a wide range of sample prep applications.

Isothermal processing
No heat damage, higher recovery
Non-contact, closed vessel
No cross contamination, no aerosols, no clean up
Precisely controlled and adjustable energy delivery
Standardized processes, highly reproducible
Automation ready
Integrates into customers’ sample processing work flow
Multi-sample capability
Higher productivity, less operator intervention
Broad sample volume range
One instrument for multiple applications
ItemSize Application Price
E220 Focused-ultrasonicator

1 Unit

Automation Next Gen Sequencing Shearing Please Inquire

Technical Specification

Treatment System
Bench-top; high intensity acoustic transducer, temperature monitoring device, circulation pump, water bath with safety enclosure
Treatment Power
100 Watts Average Power
24” (width) x 30” (depth) x 19” (height) (61cm x 76cm x 48cm)
Approximately 110 lbs (50 Kg)
Power Requirements
100-240 VAC 500 VA, 50-60 Hz
Ambient Temperature for usage
19°C to 25°C  (66°F to 77°C)
Relative humidity requirement
30% to 70%
Required Water Bath Temperature 
+5C to +40C; Controllable
Water to use
Distilled or deionized water only
Computer and Operating System

Notebook compatible; available with system from Covaris

Microsoft Windows XP SP3 minimum or Windows 7

Broad Range of Applications

In life science and pharmaceutical research, the following are some of the areas E-Series are used:
  • DNA fragmentation
  • Compound formulation
  • Chromatin shearing
  • High-throughput chemistry
  • RNA Extraction
  • Tissue disruption and homogenization
  • Cell spore and organelle Lysis
  • Sample extraction for metabolic and proteomic profiling
  • Nanoparticle formation – micronization
  • ADME/Tox extractions
  • Compound dissolution

Complimentary Products

  • AFA compatible tubes and consumables
  • microTUBES
  • miniTUBES
  • 96 microTUBE Plates
  • 8 microTUBE Strip

Regulatory Certifications

CE, ETL Mark (for Product Safety), WEEE


Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements”


Complies with radio frequency emissions and immunity requirements for Class A Industrial/Scientific/Medical (ISM) equipment under EN 61326-1:2005, as well as EN 61000-3-2:2004 and EN61000-3-3:1995. These standards meet the essential requirements of the EU EMC Directive 2004/108/EC. Additionally, the instrument meets FCC Part 15 Class A radio emissions requirements for the USA and ICES-003 Class A for Industry Canada.

Please Inquire