Catalog No. : COV-500217

S220 Focused-ultrasonicator

S220 Focused-ultrasonicator


High performance, Ultrasonicator for samples of mass <1000mg and/or volume <10ml

The S220 Focused-ultrasonicator is a versatile, high power system engineered for pre-analytical sample processing with Covaris’ patented Adaptive Focused Acoustics™. Utilizing a spherical acoustic transducer, specifically designed AFA™ Tubes, and advanced electronics, AFA delivers controlled energy precisely and accurately to sample volumes from 15 μl to 10 ml.

The versatility of the S220 Focused-ultrasonicator makes it possible to bring the advantages of AFA to numerous biological and chemical applications including, DNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization.

The S220 Focused-ultrasonicator is computer controlled by SonoLab™ Software, incorporating preset protocols for standard methods, such as DNA shearing to specific fragment lengths, and easy-to-use-tools for user-defined protocols. The S220 is also compatible with ActiveX control if required for more specialized customer-defined, laboratory automation applications.

Focused-ultrasonicators with AFA Technology operate at high frequencies (500KHz) and, therefore, unlike traditional low frequency laboratory sonicators. AFA is inaudible and does not require sound-proof boxes, hearing protectors, or other unusual precautions for their operation.

The S220 Focused-ultrasonicator is available in higher power (S220X) and robotic capable (S220R) configurations.

Features Include

Continuous Temperature Control

No heat damage, higher recovery

Non-contact, closed vessel

No cross contamination, no aerosols, no clean up

Accurate, Precise, and Controlled acoustic energy

Processes and protocols are highly reproducible

Accommodates a broad sample volume range

Multiple applications are accommodated in a single instrument


AFA is inaudible so no sound-proofing or special precautions needed

ItemSize Application Price
S220 Focused-ultrasonicator

1 Unit

Automation Shearing Next Gen Sequencing Please Inquire

S220 Focused-ultrasonicator
Treatment System
Bench-top; high intensity acoustic transducer, temperature monitoring device, circulation pump, water bath with safety enclosure
Treatment Power
100 Watts Average Power
8” Width x 21” Depth x 13” Height (20 cm x 53 cm x 33 cm)
Approximately 26 lbs (12 kg)
Power Requirements
100-240 VAC 500 VA, 50-60 Hz
Operating Conditions

Ambient Temperature: 19°C to 25°C  (66°F to 77°C)

Relative humidity: 30% to 70%

Water Bath Temperature: +5C to +40C; Controllable

Water: Distilled or deionized water only


Notebook compatible; available with system from Covaris

Operating System: Microsoft Windows XP SP3 minimum or Windows 7

Software: SonoLab 7

Regulatory Certifications
CE, ETL Mark (for Product Safety), WEEE
Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements”
Complies with radio frequency emissions and immunity requirements for Class A Industrial/Scientific/Medical (ISM) equipment under EN 61326-1:2005, as well as EN 61000-3-2:2004 and EN61000-3-3:1995. These standards meet the essential requirements of the EU EMC Directive 2004/108/EC. Additionally, the instrument meets FCC Part 15 Class A radio emissions requirements for the USA and ICES-003 Class A for Industry Canada.

S220 AFA Ultrasonicator is a versatile tool for a broad range of applications, including

  • DNA Shearing for NGS
  • Chromatin Shearing
  • Tissue homogenization for Cell lysis
  • Tissue homogenization forDrug Delivery and Formulation

Related Products

Tubes and vessels engineered for AFA compatibility:

  • AFA™ Tubes

AFA Compatible Kits and Reagents:

  • t-PREP™ System for Biomarker Extraction
  • truChIP™ Chromatin Shearing Kits
  • cryoPREP Extraction Systems

S220 Accessories:

  • Water Conditioning System
  • S-Series holders
Please Inquire

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